Structure-based design for selective inhibition lowers toxicity
نویسندگان
چکیده
منابع مشابه
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Nek2 (NIMA-related kinase 2) is a cell cycle-dependent serine/threonine protein kinase that regulates centrosome separation at the onset of mitosis. Overexpression of Nek2 is common in human cancers and suppression can restrict tumor cell growth and promote apoptosis. Nek2 inhibition with small molecules, therefore, offers the prospect of a new therapy for cancer. To achieve this goal, a better...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2013
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2013.1